Serum metabolomic biomarkers of dementia
2014 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 4, no 2, 252-62 p.Article in journal (Refereed) Published
Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.
Place, publisher, year, edition, pages
2014. Vol. 4, no 2, 252-62 p.
Memory, Early diagnosis, Alzheimer’s disease, Vascular dementia, Gas chromatography
IdentifiersURN: urn:nbn:se:umu:diva-92543DOI: 10.1159/000364816OAI: oai:DiVA.org:umu-92543DiVA: diva2:741430