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Serum metabolomic biomarkers of dementia
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2014 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 4, no 2, 252-62 p.Article in journal (Refereed) Published
Abstract [en]

Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.

Place, publisher, year, edition, pages
2014. Vol. 4, no 2, 252-62 p.
Keyword [en]
Memory, Early diagnosis, Alzheimer’s disease, Vascular dementia, Gas chromatography
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:umu:diva-92543DOI: 10.1159/000364816OAI: oai:DiVA.org:umu-92543DiVA: diva2:741430
Available from: 2014-08-28 Created: 2014-08-28 Last updated: 2017-12-05Bibliographically approved

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Jonsson, PärAntti, HenrikAdolfsson, RolfNordin, AnnelieBergdahl, JanEriksson, KåreNyberg, Lars
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Citation style
  • apa
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