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Effects of dietary glucose and fructose upon cannabinoid CB1 receptor functionality in the rat brain: a pilot study
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Farmakologi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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2014 (Engelska)Ingår i: Life Sciences, ISSN 0024-3205, E-ISSN 1879-0631, Vol. 108, nr 2, s. 116-121Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims: A high consumption of fructose leads not only to peripheral changes in insulin sensitivity and vascular function, but also to central changes in several brain regions. Given the role of the endogenous cannabinoid system in the control of energy intake, we undertook a pilot study to determine whether a high fructose diet produced changes in brain CB1 receptor functionality. Main methods: Male rats given access ad libitum to normal chow were given either water, glucose or fructose solutions to drink. CBI receptor functionality was measured autoradiographically as the increase in [35SJGTP)/S binding produced by the agonist CP55,940. Key findings: Seven regions were investigated: the prefrontal cortex, caudate-putamen, hippocampal CAI-CA3, dentate gyrus, amygdala, and dorsomedial and ventromedial hypothalami. Two-way robust Wilcoxon analyses for each brain region indicated that the dietary treatment did not produce significant main effects upon agonist-stimulated [35S]GThyS binding in any of the regions, in contrast to a significant main effect upon both leptin and adiponectin levels in the blood. However, a MANCOVA of the data controlling for leptin and adiponectin as co-variables identified a significant effect of glucose and fructose treatment for five weeks upon the [35S]GTPI/S response in the ventromedial hypothalamus, a region of importance for regulation of appetite. Significance: It is concluded from this pilot study that palatable solutions do not produce overt changes in brain CBI receptor functionality, although subtle changes in discrete brain regions may occur.

Ort, förlag, år, upplaga, sidor
Elsevier, 2014. Vol. 108, nr 2, s. 116-121
Nyckelord [en]
Fructose, Endocannabinoid, fructose, endocannabinoid, CB1 receptors, [S-35]GTP gamma S autoradiography, leptin, adiponectin
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-91832DOI: 10.1016/j.lfs.2014.05.019ISI: 000339367100008OAI: oai:DiVA.org:umu-91832DiVA, id: diva2:742281
Tillgänglig från: 2014-09-01 Skapad: 2014-08-18 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Rojo, Maria LuisaCipriano, MariateresaSöderstrom, IngegerdSimonyte, KotrynaOlsson, TommyFowler, Christopher J.

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Rojo, Maria LuisaCipriano, MariateresaSöderstrom, IngegerdSimonyte, KotrynaOlsson, TommyFowler, Christopher J.
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