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Cloxacillin concentrations in serum, subcutaneous fat, and muscle in patients with chronic critical limb ischemia
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology.
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2014 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 70, no 8, 957-963 p.Article in journal (Refereed) Published
Abstract [en]

Patients suffering from critical limb ischemia (CLI) have poor wound healing in the ankle and foot areas. Secondary wound infections are frequent and often treated with prolonged courses of antibiotics. This study set out to investigate to what extent the unbound fraction of 4 g of cloxacillin i.v. reaches its target organ in poorly vascularized tissues, i.e., the calf and foot of patients suffering from CLI. Cloxacillin concentrations were measured by HPLC in serum and in microdialysis samples from skin and muscle of the lower part of the calf and as reference subcutaneously at the pectoral level in eight patients suffering from CLI (four males, four females, mean age 78 years, range 66-85 years) and in three healthy controls (two females, one male, mean age 67, range 66-68 years). In patients suffering from CLI, the tissue penetration of cloxacillin after a single 4 g dose was comparable to that of healthy controls, despite impaired blood circulation. The reduced blood flow in the peripheral vessels of the CLI patients presented here apparently is not the rate-limiting factor for delivery or tissue penetration of cloxacillin.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2014. Vol. 70, no 8, 957-963 p.
Keyword [en]
Tissue cloxacillin concentration, Critical limb ischemia, Microdialysis, Pharmacokinetics, Tissue ischemia, Antibiotic treatment, Interstitial fluid
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:umu:diva-91819DOI: 10.1007/s00228-014-1695-9ISI: 000339332700009OAI: diva2:742472
Available from: 2014-09-01 Created: 2014-08-18 Last updated: 2014-09-01Bibliographically approved

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Nilsson, Torbjörn KSchneede, Jörn
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