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A MEMS-based passive hydrocephalus shunt for body position controlled intracranial pressure regulation
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.ORCID iD: 0000-0001-6451-1940
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2014 (English)In: Biomedical microdevices (Print), ISSN 1387-2176, E-ISSN 1572-8781, Vol. 16, no 4, 529-536 p.Article in journal (Refereed) Published
Abstract [en]

This paper reports a novel micro electro mechanical system (MEMS) valve with posture controlled flow characteristics for improved treatment of hydrocephalus, a disease that is characterized by elevated pressure in the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord. In contrast to conventional differential pressure CSF valves, the CSF valve presented here features a third port which utilizes hydrostatic pressure from a pressure compensating catheter to adapt CSF drainage to optimized levels irrespective of body position. Prototypes have been fabricated using standard MEMS manufacturing processes and the experimental evaluation successfully showed that the flow rate was adjustable with a varying hydrostatic pressure on the third port. Measured data showed that flow rate was at near ideal values at laying body position and that the flow rate can be adjusted to optimal values at standing body position by selecting an appropriate length of the pressure compensating catheter. This is the first pressure balanced CSF valve intended for body position controlled CSF pressure regulation.

Place, publisher, year, edition, pages
Springer Netherlands, 2014. Vol. 16, no 4, 529-536 p.
Keyword [en]
MEMS, Hydrocephalus, Cerebrospinal fluid (CSF), Normal pressure, Micro fluidic valve, Passive pressure balancing
National Category
Biomedical Laboratory Science/Technology Nano Technology
URN: urn:nbn:se:umu:diva-91817DOI: 10.1007/s10544-014-9855-3ISI: 000339112600004OAI: diva2:742476
Available from: 2014-09-01 Created: 2014-08-18 Last updated: 2015-10-01Bibliographically approved

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Eklund, AndersMalm, Jan
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