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High adherence to a gluten-free diet in adolescents with screening-detected celiac disease
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.ORCID-id: 0000-2021-0028-7401
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2015 (Engelska)Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 60, nr 1, s. 54-59Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: To evaluate the gluten-free diet (GFD) adherenceafter one year of follow-up in children with screening-detected celiac disease (CD) in a general population. METHODS: A total of 18,325 12 year olds were invited to participate in apopulation-based CD screening (ETICS- Exploring the Iceberg of Celiacs in Sweden), of whom 13,279 participated. In 240 children, CD was detected through elevated anti-tissue transglutaminase antibodies 2 (TG2-IgA) and verified by a small-intestinal biopsy. This sub-study included the 210 children with TG2-IgAevaluated both at the initialbiopsy occasion and at the one-year follow-up. GFD adherence was evaluated by a combination of TG2-IgA measurements and self-reported adherence (n = 193). RESULTS: After one year, 83% (179/210) had normalizedTG2-IgA levels (<5U/mL). Among those who had >50 U/mL at diagnosis,25% (16/63) still had elevated TG2-IgA but for the majority their initial values were more than halved. Most reported a high level ofGFD adherence ('always' 75%(158/193) and 'often' 14%(30/193)), and 75% (145/193) reported always adhereingcombined with normalized TG2-IgA. Although reporting that they were always adherent, 13 (6.7%) had not yet normalized their TG2-IgA levels completely, however, a majority of these initially had the highestTG2-IgA levels. CONCLUSIONS: GFD adherence is high in adolescents with CD detected by screening of the general population of Swedish 12yearolds. Almost all had normalized serology and reported GFD adherenceat the one-year follow-up. However, a few adolescents whoreported GFD adherence still had elevated TG2-IgA levelssuggesting more severe disease and/or non-adherence.

Ort, förlag, år, upplaga, sidor
Lippincott Williams & Wilkins, 2015. Vol. 60, nr 1, s. 54-59
Nyckelord [en]
adolescents, anti-tissue transglutaminase antibodies, celiac disease, gluten-free diet, screening
Nationell ämneskategori
Pediatrik Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Gastroenterologi Näringslära
Identifikatorer
URN: urn:nbn:se:umu:diva-93535DOI: 10.1097/MPG.0000000000000571ISI: 000348460100017PubMedID: 25238121OAI: oai:DiVA.org:umu-93535DiVA, id: diva2:749429
Tillgänglig från: 2014-09-24 Skapad: 2014-09-24 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Myléus, AnnaNorström, FredrikLagerqvist, CarinaRosén, AnnaSandström, OlofIvarsson, Anneli

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Myléus, AnnaNorström, FredrikLagerqvist, CarinaRosén, AnnaSandström, OlofIvarsson, Anneli
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Epidemiologi och global hälsaPediatrik
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Journal of Pediatric Gastroenterology and Nutrition - JPGN
PediatrikFolkhälsovetenskap, global hälsa, socialmedicin och epidemiologiGastroenterologiNäringslära

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