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Perceived articulatory precision in patients with Parkinson’s disease after deep brain stimulation of subthalamic nucleus and caudal zona incerta
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
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2015 (English)In: Clinical Linguistics & Phonetics, ISSN 0269-9206, E-ISSN 1464-5076, Vol. 29, no 2, 150-166 p.Article in journal (Refereed) Published
Abstract [en]

The effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and caudal zona incerta (cZi) on speech articulation in patients with Parkinson’s disease (PD) was investigated. Read speech samples were collected from nine patients with STN-DBS and ten with cZi-DBS. The recordings were made preoperatively and 12 months postoperatively with stimulator on and off (on medication). Blinded, randomized, repeated perceptual assessments were performed on words and isolated fricatives extracted from the recordings to assess 1) overall articulatory quality ratings, 2) frequency of occurrence of misarticulation patterns, and 3) fricative production. Statistically significant worsening of articulatory measures on- compared with off-stimulation occurred in the cZi-DBS group, with deteriorated articulatory precision ratings, increased presence of misarticulations (predominately altered realizations of plosives and fricatives) and a reduced accuracy in fricative production. A similar, but not significant, trend was found for the STN-DBS group. 

Place, publisher, year, edition, pages
2015. Vol. 29, no 2, 150-166 p.
Keyword [en]
Assessment, deep brain stimulation, dysarthria, Parkinson’s disease, phonetics
National Category
Other Medical Sciences not elsewhere specified
Research subject
Linguistics; Neurosurgery
Identifiers
URN: urn:nbn:se:umu:diva-93676DOI: 10.3109/02699206.2014.971192ISI: 000348045700005PubMedID: 25333411OAI: oai:DiVA.org:umu-93676DiVA: diva2:750799
Projects
En kontrastiv och longitudinell studie gällande effekten av djup hjärnstimulering på Parkinsons-patienters artikulatoriska förmåga.
Funder
Swedish Research Council, 2009-946Swedish Research Council, 2011-2294
Available from: 2014-09-30 Created: 2014-09-30 Last updated: 2017-12-05Bibliographically approved

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Eklund, ElisabethQvist, JohannaSandström, LenaDoorn, Jan vanKarlsson, Fredrik

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Eklund, ElisabethQvist, JohannaSandström, LenaViklund, FannyDoorn, Jan vanKarlsson, Fredrik
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