Perceived articulatory precision in patients with Parkinson’s disease after deep brain stimulation of subthalamic nucleus and caudal zona incerta
2015 (English)In: Clinical Linguistics & Phonetics, ISSN 0269-9206, E-ISSN 1464-5076, Vol. 29, no 2, 150-166 p.Article in journal (Refereed) Published
The effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and caudal zona incerta (cZi) on speech articulation in patients with Parkinson’s disease (PD) was investigated. Read speech samples were collected from nine patients with STN-DBS and ten with cZi-DBS. The recordings were made preoperatively and 12 months postoperatively with stimulator on and off (on medication). Blinded, randomized, repeated perceptual assessments were performed on words and isolated fricatives extracted from the recordings to assess 1) overall articulatory quality ratings, 2) frequency of occurrence of misarticulation patterns, and 3) fricative production. Statistically significant worsening of articulatory measures on- compared with off-stimulation occurred in the cZi-DBS group, with deteriorated articulatory precision ratings, increased presence of misarticulations (predominately altered realizations of plosives and fricatives) and a reduced accuracy in fricative production. A similar, but not significant, trend was found for the STN-DBS group.
Place, publisher, year, edition, pages
2015. Vol. 29, no 2, 150-166 p.
Assessment, deep brain stimulation, dysarthria, Parkinson’s disease, phonetics
Other Medical Sciences not elsewhere specified
Research subject Linguistics; Neurosurgery
IdentifiersURN: urn:nbn:se:umu:diva-93676DOI: 10.3109/02699206.2014.971192ISI: 000348045700005PubMedID: 25333411OAI: oai:DiVA.org:umu-93676DiVA: diva2:750799
ProjectsEn kontrastiv och longitudinell studie gällande effekten av djup hjärnstimulering på Parkinsons-patienters artikulatoriska förmåga.
FunderSwedish Research Council, 2009-946Swedish Research Council, 2011-2294