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In Vivo Prediction of Tuberculosis-Associated Cavity Formation in Rabbits
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
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2015 (English)In: The Journal of infectious diseases, ISSN 1537-6613, Vol. 211, no 3, 481-485 p.Article in journal (Refereed) Published
Abstract [en]

The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [(18)F]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.

Place, publisher, year, edition, pages
2015. Vol. 211, no 3, 481-485 p.
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Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-93715DOI: 10.1093/infdis/jiu449ISI: 000350221500018PubMedID: 25117755OAI: oai:DiVA.org:umu-93715DiVA: diva2:750903
Available from: 2014-09-30 Created: 2014-09-30 Last updated: 2015-05-08Bibliographically approved

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Larsson, Christer
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