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Life style intervention in moderately overweight individuals is associated with decreased levels of cathepsins L and S in plasma
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Sports Medicine.
2014 (English)In: Annals of Clinical and Laboratory Science, ISSN 0091-7370, Vol. 44, no 3, 283-285 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality. OBJECTIVE: The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma. METHOD: Study subjects (n=31) were recruited to a life style intervention program aiming at increased physical activity, more healthy eating habits, and weight reduction for most of the participants. Blood samples were collected at inclusion and after 4 and 8 weeks. RESULTS: Cathepsin L was significantly reduced at 4 weeks (p<0.0001) and 8 weeks (p=0.0004). A similar reduction was also seen for cathepsin S at 4 weeks (p=0.03) and 8 weeks (p=0.008). No significant change in fractalkine values was observed at 4 weeks (p=0.58), but a significant increase was apparent at 8 weeks (p=0.0002). CONCLUSION: The intervention program resulted in significant reductions of cathepsin L and S levels in plasma after 4 and 8 weeks of intervention.

Place, publisher, year, edition, pages
The Association of Clinical Scientists , 2014. Vol. 44, no 3, 283-285 p.
Keyword [en]
adult; body weight; cathepsin L; cathepsin S; fractalkine; human; weight reduction
National Category
Sport and Fitness Sciences Medical Laboratory and Measurements Technologies
URN: urn:nbn:se:umu:diva-93858ISI: 000344755600007PubMedID: 25117098OAI: diva2:751493
Available from: 2014-10-01 Created: 2014-10-01 Last updated: 2014-12-12Bibliographically approved

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