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Ruled by ubiquitylation: a new order for Polycomb recruitment
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2014 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 8, no 2, 321-325 p.Article in journal (Refereed) Published
Abstract [en]

Polycomb complexes are found in most cells, but they must be targeted to specific genes in specific cell types in order to regulate pluripotency and differentiation. The recruitment of Polycomb complexes to specific targets has been widely thought to occur in two steps: first, one complex, PRC2, produces histone H3 lysine 27 (H3K27) trimethylation at a specific gene, and then the PRC1 complex is recruited by its ability to bind to H3K27me3. Now, three new articles turn this model upside-down by showing that binding of a variant PRC1 complex and subsequent H2A ubiquitylation of surrounding chromatin is sufficient to trigger the recruitment of PRC2 and H3K27 trimethylation. These studies also show that ubiquitylated H2A is directly sensed by PRC2 and that ablation of PRC1-mediated H2A ubiquitylation impairs genome-wide PRC2 binding and disrupts mouse development.

Place, publisher, year, edition, pages
Cell Press , 2014. Vol. 8, no 2, 321-325 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-94164DOI: 10.1016/j.celrep.2014.07.001ISI: 000341569800001OAI: oai:DiVA.org:umu-94164DiVA: diva2:752715
Available from: 2014-10-06 Created: 2014-10-06 Last updated: 2017-12-05Bibliographically approved

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