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Significant beat-to-beat variability of E/e’ irrespective of respiration
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
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2013 (English)In: International cardiovascular forum, ISSN 2409-3424, Vol. 1, no 2, 88-89 p.Article in journal (Refereed) Published
Abstract [en]

The E/e’ ratio is commonly used in Doppler echocardiographic examinations to estimate the pulmonary capillary wedge pressure. The rationale of using this ratio is to combine left ventricular (LV) filling (E) and relaxation (e’) velocities to indirectly assess left atrial pressure. However, the accuracy of this index has recently been questioned, particularly in patients with controlled heart failure. Likewise, the potential beat-to-beat variability of such measurements remains undetermined. The cardiovascular system is subject to several oscillations with the potential of influencing LV function and its intra-cavitary pressures, hence measurements of its filling and relaxation velocities. The aim of this pilot study was to assess the beat-to-beat variability of the E/e’ ratio in one minute long examination in healthy subjects, and patients with various severity of amyloid heart disease. The results show that despite critical application of the standard echocardiographic recording recommendations, E/e’ beat-to-beat variability was 36 % (22 to 50%) in healthy subjects and 17 % (11-26%) in patients, and where the most severe amyloid heart disease had the least variability. Thus, clinical use of a single or few cardiac beats might not necessarily reflect an accurate ratio between the two velocities, and hence casts doubt over their diagnostic value.

Place, publisher, year, edition, pages
Barcaray Publishing , 2013. Vol. 1, no 2, 88-89 p.
Keyword [en]
Echocardiography, E/e’, variability, Amyloid, color Doppler
National Category
Medical Engineering Medical Image Processing Cardiac and Cardiovascular Systems
Research subject
Cardiology; Medicine, cardiovascular disease
URN: urn:nbn:se:umu:diva-94196DOI: 10.17987/icfj.v1i2.27OAI: diva2:752724
Available from: 2014-10-06 Created: 2014-10-06 Last updated: 2015-12-16Bibliographically approved

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Grönlund, ChristerGustavsson, SandraHenein, Michael YLindqvist, Per
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ReferencesLink to record
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