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From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries
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2014 (English)In: Clinical and Experimental Rheumatology, ISSN 0392-856X, E-ISSN 1593-098X, Vol. 32, no 4, 539-546 p.Article in journal (Refereed) Published
Abstract [en]


One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD).


A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries.


The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries.


Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.

Place, publisher, year, edition, pages
2014. Vol. 32, no 4, 539-546 p.
Keyword [en]
anti-nuclear antibodies, extractable nuclear antigens, systemic autoimmune rheumatic diseases, harmonisation, algorithm
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-93839ISI: 000341171000015PubMedID: 24983380OAI: diva2:753248
Available from: 2014-10-07 Created: 2014-10-01 Last updated: 2014-10-07Bibliographically approved

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Eriksson, Catharina
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