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The biology of bone remodelling in jaw bones with and without teeth
Umeå University, Faculty of Medicine, Department of Odontology.
2012 (English)In: Textbook of removable prosthodontics: the Scandinavian approach / [ed] Margareta Molin Thorén och Johan Gunne, Munksgaard Forlag, 2012, 1, 51-60 p.Chapter in book (Refereed)
Abstract [en]

Bone tissues, together with enamel, dentin and cementum, are unique tissues in the human body because of the presence of large amounts of mineral crystals in the extracellular matrix. It is a common misconception that mineralized tissues of the body are dead tissues with the only task of forming the skeleton and the teeth. However, bone tissue is a living organ with different cell types that have important functions for mineral homeostasis and for remodelling as well as modelling of the skeleton in order to renew it and to adapt to functional demands. Two morphologically distinct bone tissues make up all bones; the cortical bones in the periphery and the network of trabecular bone in the inner part of the bones. Some bones have only small amounts of trabecular bone, whereas others are filled up more densely. It is not known why some osteoblasts are producing cortical bone and others trabecular bone. Interestingly, trabecular bone is more frequently remodelled. This is the reason why metabolic bone diseases, such as osteoporosis, affect bone with large amounts of trabecular bone more severely. Much remains to be understood about the different processes of bone formation, how it is controlled and why we have two types of bone. Although the general view is that all osteoblasts and osteoclasts in the body are very similar, it has become clearer during recent years that a substantial heterogeneity exists in osteoblasts and osteoclasts present in different bones. Most studies are performed on bone cells isolated from calvarial bones and long bones and very few from jaw bones. This is important, since the biology of osteoblasts and osteoclasts in maxilla and mandible is not necessarily similar in all aspects to the one observed in cells from other areas. This chapter presents a brief summary of bone cell biology, bone remodelling and modelling including the effects by inflammatory processes on bone cell activities and, finally, summarizes the relatively spare information available on bone remodelling in the vicinity of removable prosthetic dentures.

Place, publisher, year, edition, pages
Munksgaard Forlag, 2012, 1. 51-60 p.
National Category
URN: urn:nbn:se:umu:diva-94398ISBN: 9788762809550OAI: diva2:753622
Available from: 2014-10-08 Created: 2014-10-08 Last updated: 2015-08-24Bibliographically approved

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Lerner, Ulf H
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