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Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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2015 (Engelska)Ingår i: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 39, nr 2, s. 303-311Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Black women have lower visceral adipose tissue (VAT) but are less insulin sensitive than white women; the mechanisms responsible are unknown.

Objective: The study aimed to test the hypothesis that variation in subcutaneous adipose tissue (SAT) sensitivity to glucocorticoids might underlie these differences.

Methods: Body fatness (dual energy X-ray absorptiometry) and distribution (computerized tomography), insulin sensitivity (SI, intravenous and oral glucose tolerance tests), and expression of 11β-hydroxysteroid dehydrogenase-1 (11HSD1), hexose-6-phosphate dehydrogenase and glucocorticoid receptor-α (GRα), as well as genes involved in adipogenesis and inflammation were measured in abdominal deep SAT, superficial SAT and gluteal SAT (GLUT) depots of 56 normal-weight or obese black and white premenopausal South African (SA) women. We used a combination of univariate and multivariate statistics to evaluate ethnic-specific patterns in adipose gene expression and related body composition and insulin sensitivity measures.

Results: Although 11HSD1 activity and mRNA did not differ by ethnicity, GRα mRNA levels were significantly lower in SAT of black compared with white women, particularly in the GLUT depot (0.52±0.21 vs 0.91±0.26 AU, respectively, P<0.01). In black women, lower SAT GRα mRNA levels were associated with increased inflammatory gene transcript levels and abdominal SAT area, and reduced adipogenic gene transcript levels, VAT/SAT ratio and SI. Abdominal SAT 11HSD1 activity associated with increased VAT area and decreased SI in white, but not in black women.

Conclusions: In black SA women, downregulation of GRα mRNA levels with obesity and reduced insulin sensitivity, possibly via increased SAT inflammation, is associated with reduced VAT accumulation.

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2015. Vol. 39, nr 2, s. 303-311
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Endokrinologi och diabetes Näringslära
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URN: urn:nbn:se:umu:diva-94495DOI: 10.1038/ijo.2014.94ISI: 000349553200016PubMedID: 24854429OAI: oai:DiVA.org:umu-94495DiVA, id: diva2:754364
Tillgänglig från: 2014-10-10 Skapad: 2014-10-10 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Chorell, ElinOlsson, Tommy

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