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Herpes simplex infection and the risk of Alzheimer's disease: a nested case-control study
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Odontology, School of Dentistry. (Aa-gruppen)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
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2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 6, 587-592 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD).

METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays.

RESULTS: In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019).

CONCLUSION: Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD.

Place, publisher, year, edition, pages
2015. Vol. 11, no 6, 587-592 p.
Keyword [en]
Alzheimers, Herpes simplex viruses
National Category
Neurology Neurosciences
Research subject
Infectious Diseases
Identifiers
URN: urn:nbn:se:umu:diva-94526DOI: 10.1016/j.jalz.2014.07.157ISI: 000357231900001PubMedID: 25304990OAI: oai:DiVA.org:umu-94526DiVA: diva2:754767
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Available from: 2014-10-12 Created: 2014-10-12 Last updated: 2017-12-05Bibliographically approved

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Lövheim, HugoGilthorpe, JonathanJohansson, AndersEriksson, StureHallmans, GöranElgh, Fredrik

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Lövheim, HugoGilthorpe, JonathanJohansson, AndersEriksson, StureHallmans, GöranElgh, Fredrik
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Geriatric MedicineClinical NeuroscienceNutritional ResearchSchool of DentistryDepartment of Biobank ResearchVirology
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Alzheimer's & Dementia
NeurologyNeurosciences

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