Herpes simplex infection and the risk of Alzheimer's disease: a nested case-control study
2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 6, 587-592 p.Article in journal (Refereed) Published
BACKGROUND: Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD).
METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays.
RESULTS: In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019).
CONCLUSION: Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD.
Place, publisher, year, edition, pages
2015. Vol. 11, no 6, 587-592 p.
Alzheimers, Herpes simplex viruses
Research subject Infectious Diseases
IdentifiersURN: urn:nbn:se:umu:diva-94526DOI: 10.1016/j.jalz.2014.07.157ISI: 000357231900001PubMedID: 25304990OAI: oai:DiVA.org:umu-94526DiVA: diva2:754767