Effect of infancy-onset dietary intervention on salivary cholesterol of children: a randomized controlled trial
2011 (English)In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 90, no 7, 868-873 p.Article in journal (Refereed) Published
This study investigated salivary cholesterol of children from 6 to 16 years of age in response to dietary intervention. One thousand sixty-two infants started in the prospective, randomized project. At 3 years of age, every fifth child was invited into the study (n=178). Of these, 148 enrolled, and 86 completed the oral sub-study at 16 years of age. The intervention aimed at restricting the child's saturated fat and cholesterol intake. Control children received no special recommendations. Every third year, paraffin-stimulated saliva samples (10.0 mL) were collected for cholesterol assays. Nutrient intakes and serum total cholesterol concentrations were regularly followed up by means of 4-day food records and blood samples. Intake of saturated fatty acids (SAFA) was lower in the intervention than in the control group (p<0.001). Salivary cholesterol concentration increased from 1.9 (±1.1) µmol/L at 6 years of age to 16.0 (±9.0) µmol/L at 16 years of age. The increase was smaller in the intervention than in the control group (p<0.001). The ratios of salivary to serum cholesterol concentrations tended to be higher in boys than in girls (p=0.07). Thus, dietary intervention was reflected in children's salivary cholesterol values more sensitively than in serum cholesterol values. (clinicaltrials.gov NCT00223600).
Place, publisher, year, edition, pages
Sage Publications, 2011. Vol. 90, no 7, 868-873 p.
salivary and serum lipids, children, prevention, salivary diagnostics
IdentifiersURN: urn:nbn:se:umu:diva-95212DOI: 10.1177/0022034511405328ISI: 000291696900008PubMedID: 21474838OAI: oai:DiVA.org:umu-95212DiVA: diva2:757967