Change search
ReferencesLink to record
Permanent link

Direct link
Effect of infancy-onset dietary intervention on salivary cholesterol of children: a randomized controlled trial
Umeå University, Faculty of Medicine, Department of Odontology.
Show others and affiliations
2011 (English)In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 90, no 7, 868-873 p.Article in journal (Refereed) Published
Abstract [en]

This study investigated salivary cholesterol of children from 6 to 16 years of age in response to dietary intervention. One thousand sixty-two infants started in the prospective, randomized project. At 3 years of age, every fifth child was invited into the study (n=178). Of these, 148 enrolled, and 86 completed the oral sub-study at 16 years of age. The intervention aimed at restricting the child's saturated fat and cholesterol intake. Control children received no special recommendations. Every third year, paraffin-stimulated saliva samples (10.0 mL) were collected for cholesterol assays. Nutrient intakes and serum total cholesterol concentrations were regularly followed up by means of 4-day food records and blood samples. Intake of saturated fatty acids (SAFA) was lower in the intervention than in the control group (p<0.001). Salivary cholesterol concentration increased from 1.9 (±1.1) µmol/L at 6 years of age to 16.0 (±9.0) µmol/L at 16 years of age. The increase was smaller in the intervention than in the control group (p<0.001). The ratios of salivary to serum cholesterol concentrations tended to be higher in boys than in girls (p=0.07). Thus, dietary intervention was reflected in children's salivary cholesterol values more sensitively than in serum cholesterol values. ( NCT00223600).

Place, publisher, year, edition, pages
Sage Publications, 2011. Vol. 90, no 7, 868-873 p.
Keyword [en]
salivary and serum lipids, children, prevention, salivary diagnostics
National Category
URN: urn:nbn:se:umu:diva-95212DOI: 10.1177/0022034511405328ISI: 000291696900008PubMedID: 21474838OAI: diva2:757967
Available from: 2014-10-24 Created: 2014-10-24 Last updated: 2015-10-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, BJohansson, Ingegerd
By organisation
Department of Odontology
In the same journal
Journal of Dental Research

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link