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Growth-limiting role of endothelial cells in endoderm development
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
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2011 (English)In: Developmental Biology, ISSN 0012-1606, E-ISSN 1095-564X, Vol. 352, no 2, 267-277 p.Article in journal, Editorial material (Refereed) Published
Abstract [en]

Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs.

Place, publisher, year, edition, pages
Academic Press, 2011. Vol. 352, no 2, 267-277 p.
Keyword [en]
Animals, Cell Size, Computational Biology, Female, Image, Enhancement, Imaging, Three-Dimensional, Insulin-Secreting Cells, Islets of Langerhans, Mice, Mice, Inbred C57BL, Organ Size, Pancreas, Pancreas, Exocrine, Reproducibility of Results, Tomography, Optical
National Category
Cell and Molecular Biology
Research subject
Molecular Medicine
URN: urn:nbn:se:umu:diva-95238DOI: 10.1016/j.ydbio.2011.01.026ISI: 000289180200008PubMedID: 21281624OAI: diva2:758135
Available from: 2014-10-24 Created: 2014-10-24 Last updated: 2015-10-23Bibliographically approved

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Hörnblad, AndreasLorén, ChristinaAhlgren, Ulf
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