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Growth-limiting role of endothelial cells in endoderm development
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
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2011 (English)In: Developmental Biology, ISSN 0012-1606, E-ISSN 1095-564X, Vol. 352, no 2, 267-277 p.Article in journal, Editorial material (Refereed) Published
Abstract [en]

Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs.

Place, publisher, year, edition, pages
Academic Press, 2011. Vol. 352, no 2, 267-277 p.
Keyword [en]
Animals, Cell Size, Computational Biology, Female, Image, Enhancement, Imaging, Three-Dimensional, Insulin-Secreting Cells, Islets of Langerhans, Mice, Mice, Inbred C57BL, Organ Size, Pancreas, Pancreas, Exocrine, Reproducibility of Results, Tomography, Optical
National Category
Cell and Molecular Biology
Research subject
Molecular Medicine
Identifiers
URN: urn:nbn:se:umu:diva-95238DOI: 10.1016/j.ydbio.2011.01.026ISI: 000289180200008PubMedID: 21281624OAI: oai:DiVA.org:umu-95238DiVA: diva2:758135
Available from: 2014-10-24 Created: 2014-10-24 Last updated: 2017-12-05Bibliographically approved

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Hörnblad, AndreasLorén, ChristinaAhlgren, Ulf
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