Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes
2014 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 76, no 4, 394-400 p.Article in journal (Refereed) Published
BACKGROUND: Some of the health advantages of breast-fed as compared to formula-fed infants have been suggested to be due to metabolic programming effects resulting from early nutrition. METHODS: In a prospective double-blinded randomized trial, 160 infants <2 mo of age were randomized to experimental formula (EF) with added milk fat globule membrane (MFGM) or standard formula (SF) until 6 mo of age. A breast-fed reference (BFR) group consisted of 80 infants. Measurements were made at inclusion and at 4, 6, and 12 mo of age. RESULTS: During the intervention, the EF group had higher total serum cholesterol concentration than the SF group, reaching the level of the BFR group. The EF group had a low-density lipoprotein to high-density lipoprotein ratio not significantly different from the SF group but lower than the BFR group. CONCLUSION: Supplementation of infant formula with MFGM modified the fat composition of the formula and narrowed the gap between breast-fed and formula-fed infants with regard to serum lipid status at 12 mo.
Place, publisher, year, edition, pages
Nature Publishing Group, 2014. Vol. 76, no 4, 394-400 p.
IdentifiersURN: urn:nbn:se:umu:diva-95269DOI: 10.1038/pr.2014.110ISI: 000342332000010OAI: oai:DiVA.org:umu-95269DiVA: diva2:760667