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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
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2014 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 9, 994-+ p.Article in journal (Refereed) Published
Abstract [en]

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Place, publisher, year, edition, pages
2014. Vol. 46, no 9, 994-+ p.
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Medical Genetics
URN: urn:nbn:se:umu:diva-94549DOI: 10.1038/ng.3052ISI: 000341579400014OAI: diva2:761445
Available from: 2014-11-06 Created: 2014-10-13 Last updated: 2014-11-06Bibliographically approved

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Porta, MiquelSund, Malin
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Department of Surgical and Perioperative Sciences
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