Three dimensional distribution of Propionibacterium acnes biofilms in human skin
2014 (English)In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 23, no 9, 687-689 p.Article in journal (Refereed) Published
Propionibacterium acnes is regarded as a common member of the human skin microbiota, often occurring in biofilms. Little is known about the size of bacterial biofilms in hair follicles as a few sections of biopsy tissue are routinely evaluated. Transversal sectioning provides a better opportunity for histological analyses of hair follicles which can be followed through the different morphological levels. Direct visualization of P.acnes biofilms in hundreds of consecutive sections allowed insight into the 3D distribution in human hair follicles as well as investigating the depth of biofilm distribution within hair follicles. Four distinct colonization patterns of P.acnes biofilms were revealed. Results have shown that an individual P.acnes biofilm can spread for 1900m in a terminal hair follicle. This information can be of help while designing potential antibiofilm treatment.
Place, publisher, year, edition, pages
John Wiley & Sons, 2014. Vol. 23, no 9, 687-689 p.
biofilm, hair follicle, P, acnes, skin
Medical and Health Sciences
Research subject Pathology
IdentifiersURN: urn:nbn:se:umu:diva-94925DOI: 10.1111/exd.12482ISI: 000342132800019OAI: oai:DiVA.org:umu-94925DiVA: diva2:762000