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Experience-dependent plasticity of visual cortical microcircuits
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2014 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 278, 367-384 p.Article, review/survey (Refereed) Published
Abstract [en]

The recent decade testified a tremendous increase in our knowledge on how cell-type-specific microcircuits process sensory information in the neocortex and on how such circuitry reacts to manipulations of the sensory environment. Experience-dependent plasticity has now been investigated with techniques endowed with cell resolution during both postnatal development and in adult animals. This review recapitulates the main recent findings in the field using mainly the primary visual cortex as a model system to highlight the more important questions and physiological principles (such as the role of non-competitive mechanisms, the role of inhibition in excitatory cell plasticity, the functional importance of spine and axonal plasticity on a microscale level). I will also discuss on which scientific problems the debate and controversies are more pronounced. New technologies that allow to perturbate cell-type-specific subcircuits will certainly shine new light in the years to come at least on some of the still open questions. (C) 2014 The Author. Published by Elsevier Ltd. on behalf of IBRO.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 278, 367-384 p.
Keyword [en]
experience-dependent plasticity, microcircuits, layer specificity, cell-type specificity, visual system, barrel cortex
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-94938DOI: 10.1016/j.neuroscience.2014.08.022ISI: 000342058700033OAI: oai:DiVA.org:umu-94938DiVA: diva2:762637
Available from: 2014-11-12 Created: 2014-10-20 Last updated: 2017-12-05Bibliographically approved

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Medini, Paolo

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