The Swedish National Penile Cancer Register: Incidence, Tumour Characteristics, Management and Survival
2016 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 117, no 2, 287-292 p.Article in journal (Refereed) Published
OBJECTIVES: To assess penile cancer incidence, stage distribution, adherence to guidelines, and prognostic factors in a population-based setting.
PATIENTS AND METHODS: The population-based Swedish National Penile Cancer Register (NPECR) contains detailed information on tumour characteristics and management patterns. ● A total of 1678 men with primary squamous cell carcinoma of the penis identified in the NPECR between 2000 and 2012 were included in the study.
RESULTS: The mean age-adjusted incidence of penile cancer was 2.1/100,000 men, remaining virtually unchanged during the study period. At diagnosis, 14% and 2% were clinically N+ and M+, respectively. Most patients were staged pTis (34%), pT2 (19%), or pT1 (18%), whereas stage was unavailable in 18%. Organ-preserving treatment was used in 71% of Tis-T1 tumours. In cN0 and ≥pT1G2 patients, 50% underwent lymph node staging, while 74% of cN1-3 patients underwent lymph node dissection. The overall 5-year relative survival was 82%. Men aged ≥40 years and those with pT2-3, G2-3 and N+ tumours had worse outcome.
CONCLUSION: The incidence of penile cancer in Sweden is stable. Most men presented with localised disease, and the proportion of non-invasive tumours was high. During the period under study, adherence to guidelines was suboptimal. The overall 5-year relative survival was 82%. Older age, increasing tumour stage and grade, and increasing lymph node stage were associated with poorer survival.
Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 117, no 2, 287-292 p.
penile cancer, population-based, incidence, TNM, prognostic factors, survival
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-96583DOI: 10.1111/bju.12993ISI: 000367717300018PubMedID: 25395083OAI: oai:DiVA.org:umu-96583DiVA: diva2:765473
Article first published online: 4 MAY 20152014-11-242014-11-242016-05-02Bibliographically approved