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PROGNOSTIC IMPACT OF IKZF1 DELETIONS IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA TREATED ACCORDING TO NOPHO PROTOCOLS - THE SWEDISH EXPERIENCE
Umeå University, Faculty of Medicine, Department of Medical Biosciences.
Umeå University, Faculty of Medicine, Department of Medical Biosciences.
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2014 (English)In: Haematologica (online), ISSN 0390-6078, E-ISSN 1592-8721, Vol. 99, no Suppl 1, 9-9 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Recently, IKZF1 deletions have been shown to be associated notonly with the leukemogenic process but also to confer a poor prognosis in allrisk groups of B-cell precursor ALL. In a previous study, we used Multiplex Ligation-dependentProbe Amplification (MLPA) to investigate the presence ofIKZF1 deletions in bone marrow DNA from 116 children diagnosed with BCPALL in a single center and treated according to NOPHO protocols. Deletionswere detected in 16% of cases; both event free survival and overall survivalwere significantly reduced in the IKZF1-deleted group compared to the groupwith intact IKZF1.

Place, publisher, year, edition, pages
2014. Vol. 99, no Suppl 1, 9-9 p.
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Medical and Health Sciences
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URN: urn:nbn:se:umu:diva-96644ISI: 000342830900022OAI: oai:DiVA.org:umu-96644DiVA: diva2:765963
Available from: 2014-11-25 Created: 2014-11-24 Last updated: 2017-12-05Bibliographically approved

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Norén-Nyström, UlrikaForestier, ErikGolovleva, Irina

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