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Absolute quantifications of oxy- and deoxyhemoglobin concentrations by combination of differentially resolved spectroscopy and spatially resolved spectroscopy
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
2015 (English)In: Spectroscopy Letters, ISSN 0038-7010, E-ISSN 1532-2289, Vol. 48, no 3, 170-172 p.Article in journal, Letter (Refereed) Published
Abstract [en]

This letter proposes a theoretical framework to calculate absolute concentrations of oxy- and deoxyhemoglobin using continuous-wave near-infrared spectroscopy. While previous methods on this topic require assumptions on constant blood volume, the proposed method does not. Equations for the absolute concentrations were derived from a combination of the modified Beer-Lambert equation and the theory of diffusion of photons in turbid media. The method has an advantage over and is theoretically consistent with previous methods. It needs yet to be evaluated in an experimental study.

Place, publisher, year, edition, pages
Taylor & Francis, 2015. Vol. 48, no 3, 170-172 p.
Keyword [en]
NIRS, absolute quantification, differential spectroscopy, spatially resolved spectroscopy
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:umu:diva-96484DOI: 10.1080/00387010.2013.867887ISI: 000343807900003OAI: oai:DiVA.org:umu-96484DiVA: diva2:767555
Available from: 2014-12-01 Created: 2014-11-21 Last updated: 2017-12-05Bibliographically approved

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Lindkvist, MarkusGrönlund, Christer
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Radiation PhysicsCentre for Biomedical Engineering and Physics (CMTF)
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