Biological Response, in vitro, to Pulsed High-dose Rate Electrons from a Clinical Accelerator
1991 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 30, no 6, 747-751 p.Article in journal (Refereed) Published
Several studies of biological response to ionizing radiation of high absorbed dose rates have been performed, often with conflicting results. The aim of this study was to establish whether a difference between irradiation at high dose rates and at more conventional dose rates could be verified. Pulsed 50 MeV electrons from a clinical accelerator were used both for the high dose rate experiments (mean dose rate: 3.8 x 10(2) Gy/s) and the reference experiments (mean dose rate: 9.6 x 10(-2) Gy/s). In this study V-79 cells were irradiated in vitro. The experiments were carried out under both oxic and anoxic conditions. No significant difference in relative biological effectiveness (RBE) or oxygen enhancement ratio (OER) was observed at the different dose rates investigated.
Place, publisher, year, edition, pages
Oslo, Norway: Scandinavian University Press , 1991. Vol. 30, no 6, 747-751 p.
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-97400ISI: A1991GP34600014OAI: oai:DiVA.org:umu-97400DiVA: diva2:772332