Radiobiological Cell-survival Models: a Methodological Overview
1992 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 31, no 4, 433-441 p.Article in journal (Refereed) Published
A central issue in clinical radiobiological research is the prediction of responses to different radiation qualities. The, choice of cell survival and dose-response model greatly influences the results. In this context the relationship between theory and model is emphasized. Generally, the interpretations of experimental data depend on the model. Cell survival models are systematized with respect to their relations to radiobiological theories of cell kill. The growing knowledge of biological, physical, and chemical mechanisms is reflected in the formulation of new models. The present overview shows that recent modelling has been more oriented towards the stochastic fluctuations connected to radiation energy deposition. This implies that the traditional cell survival models ought to be complemented by models of stochastic energy deposition processes and repair processes at the intracellular level.
Place, publisher, year, edition, pages
1992. Vol. 31, no 4, 433-441 p.
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-97402ISI: A1992JF83500011OAI: oai:DiVA.org:umu-97402DiVA: diva2:772337