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Periodontal Disease, Renal Dysfunction and Heightened Leukocytosis.
Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth Gerontol, Baltimore, MD 21201 USA.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.ORCID iD: 0000-0003-0556-1483
Univ Maryland, Sch Med, Div Nephrol, Baltimore, MD 21201 USA.
Univ Maryland, Sch Med, Div Nephrol, Baltimore, MD 21201 USA.
2014 (English)In: Nephron. Clinical practice, ISSN 1660-8151, E-ISSN 2235-3186, Vol. 128, no 1-2, 107-114 p.Article in journal (Refereed) Published
Abstract [en]

Background:

Leukocytosis is a powerful predictor of incident chronic kidney disease (CKD) and related outcomes. However, the association between periodontitis measures and increased leukocytosis in the context of CKD has not been well described. We sought to identify which individual measures of periodontal disease may best associate with reduced estimated glomerular filtration rate (eGFR) and albuminuria, and to test if these measures were associated with increased leukocytosis in subjects with established CKD.

Methods:

We estimated, among 13,270 participants in the National Health and Nutrition Examination Survey III study, the associations between case-based definition of periodontitis, clinical attachment loss (CAL) and pocket depth (PD) as individual measures of periodontal disease, with renal function measures and leukocytosis.

Results:

In adjusted multivariate analyses, case-based definition of severe periodontitis was associated with albuminuria (β = 0.003, p = 0.01) but not with eGFR. However, CAL and PD were all individually associated with both albuminuria (β = 0.08, p < 0.001 and β = 0.06, p < 0.001, respectively) and eGFR (β = -0.05, p < 0.001 and β = -0.03, p < 0.001, respectively). We found significant associations between elevated CAL and PD with leukocytosis. Lastly, we found a marked association between the joint presence of CKD and elevated CAL or PD with leukocytosis (odds ratio (OR) 3.3, 95% confidence interval (CI) 1.4-7.5 and OR 3.2, 95% CI 1.1-9.7, respectively).

Conclusion:

Individual measures of periodontal disease are associated with renal function and heightened leukocytosis in CKD subjects. The significantly added inflammatory burden noted in CKD subjects with periodontal disease argue for targeting periodontitis treatment as part of our multifaceted approach to CKD patients. 

Place, publisher, year, edition, pages
2014. Vol. 128, no 1-2, 107-114 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-97416DOI: 10.1159/000366445ISI: 000347919800016PubMedID: 25402594OAI: oai:DiVA.org:umu-97416DiVA: diva2:772472
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2017-12-05Bibliographically approved

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