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Diet, insulin secretion and insulin sensitivity: the Dose-Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199)
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland and School of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
2014 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 112, no 9, 1530-1541 p.Article in journal (Refereed) Published
Abstract [en]

Intakes of saturated fat (SF) and dietary fibre, body mass and physical activity are all associated with the incidence of type 2 diabetes mellitus. Their relative importance for the maintenance of normal glucose metabolism is not fully known. In a population-based sample of 1114 individuals, aged 58-78 years, dietary intakes were assessed by 4 d food records and cardiorespiratory fitness as maximal oxygen uptake. Insulin secretion, insulin sensitivity, the early-phase disposition index (DI30) and the total disposition index (DI120) were assessed based on an oral glucose tolerance test. Linear associations were modelled using linear regression. Combined effects were studied by introducing SF and fibre intakes, as well as cardiorespiratory fitness and waist circumference (WC) as dichotomised variables in general linear models. Intakes of dietary fibre and whole-grain bread were positively associated with insulin sensitivity, independent of physical fitness and WC. In women, dietary fibre intake was also positively associated with DI30. The negative association of high WC with DI30 was attenuated by a combination of low SF intake and high cardiorespiratory fitness. In conclusion, dietary fibre and a combination of low SF intake and high cardiorespiratory fitness may contribute to the maintenance of normal glucose metabolism, independent of WC.

Place, publisher, year, edition, pages
2014. Vol. 112, no 9, 1530-1541 p.
Keyword [en]
Saturated fat intake, Dietary fibre intake, Cardiorespiratory fitness, Disposition index
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-96926DOI: 10.1017/S0007114514002426ISI: 000344478300014OAI: oai:DiVA.org:umu-96926DiVA: diva2:779194
Available from: 2015-01-12 Created: 2014-12-05 Last updated: 2017-12-05Bibliographically approved

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Krachler, Benno

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