2015 (English)In: Handbook on the toxicology of metals: Volume II: Specific metals / [ed] Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg, Academic Press, 2015, 4, 1209-1216 p.Chapter in book (Refereed)
Silver compounds may be absorbed through inhalation, but there are no quantitative human data on the extent of this phenomenon. Silver salts may be absorbed by up to 10-20% after ingestion. After ingestion in humans, the highest concentrations of silver are usually found in the liver and spleen, but also to some extent in the muscles, skin, and brain. The biological half-time for silver ranges from a few days for animals up to approximately 50 days for the human liver; it is possible that skin deposits have an even longer half-time, but there are no quantitative data on this for humans. Silver binds to high molecular weight proteins and metallothionein in tissue cytosol fractions. Excretion of silver from the body is primarily biliary. Silver nanoparticles have been shown to be absorbed by both inhalation and oral routes, resulting in deposition in various organ systems. Water-soluble silver compounds such as the nitrate have a local corrosive effect and may cause fatal poisoning if swallowed accidentally. Chronic exposure of humans leads to argyria, a clinical entity characterized by gray-blue pigmentation of the skin and other body viscera. Repeated exposure of animals to silver may produce anemia, cardiac enlargement, growth retardation, and degenerative changes in the liver.
Place, publisher, year, edition, pages
Academic Press, 2015, 4. 1209-1216 p.
silver, argyria, silver exposure, silver toxicology, silver nanoparticles
Environmental Health and Occupational Health
IdentifiersURN: urn:nbn:se:umu:diva-98669DOI: 10.1016/B978-0-444-59453-2.00053-6ISBN: 9780123982933OAI: oai:DiVA.org:umu-98669DiVA: diva2:783389