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Obesity attenuates gender differences in cardiovascular mortality
Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland.
UCL, Dept Epidemiol & Publ Hlth, London, England.
Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden.
UCL, Dept Med, London, England.
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2014 (English)In: Cardiovascular Diabetology, ISSN 1475-2840, Vol. 13, 144- p.Article in journal (Refereed) Published
Abstract [en]

Background: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. Methods: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. Results: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and >= 35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. Conclusions: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation.

Place, publisher, year, edition, pages
2014. Vol. 13, 144- p.
Keyword [en]
Obesity, Gender, Cardiovascular disease mortality, SPRES JP, 1990, ARTERIOSCLEROSIS, V10, P497 anworth Roger D., 2009, ADVANCES IN THE MANAGEMENT OF TESTOSTERONE DEFICIENCY, V37, P74 ngh R, 2006, ENDOCRINOLOGY, V147, P141 at Altan, 2014, CURRENT PHARMACEUTICAL DESIGN, V20, P575 gkos Faidon, 2010, NUTRITION, V26, P686 maekers D, 1998, EUROPEAN HEART JOURNAL, V19, P1334 Eon TM, 2005, JOURNAL OF BIOLOGICAL CHEMISTRY, V280, P35983 meron A. J., 2013, OBESITY REVIEWS, V14, P86 rt AM, 2002, CARDIOVASCULAR RESEARCH, V53, P678 effes MW, 2004, ANNALS OF EPIDEMIOLOGY, V14, P492 emollieres FA, 1999, ATHEROSCLEROSIS, V142, P415 ntague CT, 1997, DIABETES, V46, P342 low B, 2000, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, V85, P574 rshaw EE, 2004, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM86th Annual Meeting of the docrine-Society, JUN 12-15, 2004, New Orleans, LA, V89, P2548 G, 2003, DIABETOLOGIA, V46, P608 rason K, 1999, AMERICAN JOURNAL OF CARDIOLOGY, V83, P1242 ters HW, 1999, JOURNAL OF INTERNAL MEDICINE, V246, P521
National Category
Cardiac and Cardiovascular Systems Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-98875DOI: 10.1186/s12933-014-0144-5ISI: 000346062200001OAI: diva2:786360
Available from: 2015-02-05 Created: 2015-01-27 Last updated: 2015-04-15Bibliographically approved

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