Change search
ReferencesLink to record
Permanent link

Direct link
Developmental exposure to purity-controlled polychlorinated biphenyl congeners (PCB74 and PCB95) in rats: Effects on brainstem auditory evoked potentials and catalepsy
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2015 (English)In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 327, 22-31 p.Article in journal (Refereed) Published
Abstract [en]

Whereas the effects of dioxin-like polychlorinated biphenyls (DL-PCBs) are well described, less is known about non-dioxin-like PCBs (NDL-PCBs), including influences on the nervous system and related behavioral effects after developmental exposure. Following the examination of the highly purified NDL congeners PCB52 and PCB180, we report here the results of experiments with PCB74 and PCB95. Rat dams were orally exposed to equimolar doses of either congener (40 mu mol/kg bw - 11.68 mg PCB74/kg bw or 13.06 mg PCB95/kg bw) from gestational day (GD) 10 to postnatal day (PND) 7. Control dams were given the vehicle. Adult offspring were tested for cataleptic behavior after induction with haloperidol, a classical neuroleptic drug, and brainstem auditory evoked potentials (BAEPs), using clicks and tone pips of different frequencies for stimulation. Results revealed slight effects on latencies to movement onset in female offspring exposed to PCB74, whereas PCB74 males and offspring exposed to PCB95 were not affected. Pronounced changes were observed in BAEPs at low frequencies in PCB74 offspring, with elevated thresholds in both sexes. PCB95 increased thresholds in males, but not females. Small effects were detected on latency of the late wave IV in both sexes after developmental exposure to PCB74 or PCB95. Compared with the other NDL-PCB congeners tested, PCB74 caused the most pronounced effects on BAEPs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2015. Vol. 327, 22-31 p.
Keyword [en]
Polychlorinated biphenyls, Auditory development, Catalepsy, Dopamine, Behavior, Rats
National Category
Other Chemistry Topics
URN: urn:nbn:se:umu:diva-99772DOI: 10.1016/j.tox.2014.11.004ISI: 000347866000003OAI: diva2:789220
Available from: 2015-02-18 Created: 2015-02-12 Last updated: 2015-02-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Andersson, Patrik
By organisation
Department of Chemistry
In the same journal
Other Chemistry Topics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 52 hits
ReferencesLink to record
Permanent link

Direct link