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The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention
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2014 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 277, no 1-2, 153-159 p.Article in journal (Refereed) Published
Abstract [en]

In this cross-sectional study, we wanted to identify key cytokines characteristic of different stages of multiple sclerosis (MS). To this end, cerebrospinal fluid from patients with MS was investigated with a multiplexed fluorescent bead-based immunoassay. In total 43 cytokines were assessed and related to clinical and imaging data. Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. These homogenous patterns of cytokine activation do not conform to conventional Th1/Th2/Th17 responses. (C) 2014 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 277, no 1-2, 153-159 p.
Keyword [en]
Cerebrospinal fluid, Cytokines, Magnetic resonance imaging, Multiple sclerosis
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URN: urn:nbn:se:umu:diva-100152DOI: 10.1016/j.jneuroim.2014.10.005ISI: 000347663100019OAI: diva2:790888
Available from: 2015-02-26 Created: 2015-02-24 Last updated: 2015-02-26Bibliographically approved

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Svenningsson, Anders
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Department of Pharmacology and Clinical Neuroscience
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