Change search
ReferencesLink to record
Permanent link

Direct link
Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).ORCID iD: 0000-0001-8685-9665
2015 (English)In: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 6, 10- p.Article in journal (Refereed) Published
Abstract [en]

The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts. The reaction mechanism of ATP synthase has been studied in detail for over half a century; however, its optimal performance depends also on the steady delivery of ATP synthase substrates and the removal of its products. For mitochondrial ATP synthase, we analyze here the provision of stable conditions for (i) the supply of ADP and Mg2+, supported by adenylate kinase (AK) equilibrium in the intermembrane space, (ii) the supply of phosphate via membrane transporter in symport with H+ and (iii) the conditions of outflow of ATP by adenylate transporter carrying out the exchange of free adenylates. We also show that, in chloroplasts, AK equilibrates adenylates and governs Mg2+ contents in the stroma, optimizing ATP synthase and Calvin cycle operation, and affecting the import of inorganic phosphate in exchange with triose phosphates. It is argued that chemiosmosis is not the sole component of ATP synthase performance, which also depends on AK-mediated equilibrium of adenylates and Mg2+, adenylate transport, and phosphate release and supply.

Place, publisher, year, edition, pages
2015. Vol. 6, 10- p.
Keyword [en]
adenylate kinase, ATP synthase, chemiosmosis, chloroplasts, magnesium, mitochondria
National Category
URN: urn:nbn:se:umu:diva-100128DOI: 10.3389/fpls.2015.00010ISI: 000348447800001OAI: diva2:792210
Available from: 2015-03-03 Created: 2015-02-24 Last updated: 2015-11-06Bibliographically approved

Open Access in DiVA

fulltext(1898 kB)145 downloads
File information
File name FULLTEXT01.pdfFile size 1898 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Kleczkowski, Leszek A.
By organisation
Department of Plant PhysiologyUmeå Plant Science Centre (UPSC)
In the same journal
Frontiers in Plant Science

Search outside of DiVA

GoogleGoogle Scholar
Total: 145 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 110 hits
ReferencesLink to record
Permanent link

Direct link