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Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).ORCID iD: 0000-0001-8685-9665
2015 (English)In: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 6, 10- p.Article in journal (Refereed) Published
Abstract [en]

The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts. The reaction mechanism of ATP synthase has been studied in detail for over half a century; however, its optimal performance depends also on the steady delivery of ATP synthase substrates and the removal of its products. For mitochondrial ATP synthase, we analyze here the provision of stable conditions for (i) the supply of ADP and Mg2+, supported by adenylate kinase (AK) equilibrium in the intermembrane space, (ii) the supply of phosphate via membrane transporter in symport with H+ and (iii) the conditions of outflow of ATP by adenylate transporter carrying out the exchange of free adenylates. We also show that, in chloroplasts, AK equilibrates adenylates and governs Mg2+ contents in the stroma, optimizing ATP synthase and Calvin cycle operation, and affecting the import of inorganic phosphate in exchange with triose phosphates. It is argued that chemiosmosis is not the sole component of ATP synthase performance, which also depends on AK-mediated equilibrium of adenylates and Mg2+, adenylate transport, and phosphate release and supply.

Place, publisher, year, edition, pages
2015. Vol. 6, 10- p.
Keyword [en]
adenylate kinase, ATP synthase, chemiosmosis, chloroplasts, magnesium, mitochondria
National Category
Botany
Identifiers
URN: urn:nbn:se:umu:diva-100128DOI: 10.3389/fpls.2015.00010ISI: 000348447800001OAI: oai:DiVA.org:umu-100128DiVA: diva2:792210
Available from: 2015-03-03 Created: 2015-02-24 Last updated: 2017-12-04Bibliographically approved

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Kleczkowski, Leszek A.
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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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Language
  • de-DE
  • en-GB
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  • Other locale
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Output format
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