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Reactivated herpes simplex infection increases the risk of Alzheimer's disease
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0002-8114-7615
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 6, 593-599 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer's disease (AD).

METHODS: The present analysis included 3432 persons (53.9% women, mean age at inclusion 62.7 ± 14.4 years) with a mean follow-up time of 11.3 years. The number of incident AD cases was 245. Serum samples were analyzed for anti-HSV antibodies (immunoglobulin (Ig)G and IgM) by enzyme-linked immunosorbent assays.

RESULTS: The presence of anti-HSV IgG antibodies was not associated with an increased risk for AD, controlled for age and sex (hazard ratio, HR, 0.993, P = .979). However, the presence of anti-HSV IgM at baseline was associated with an increased risk of developing AD (HR 1.959, P = .012).

CONCLUSION: Positivity for anti-HSV IgM, a sign of reactivated infection, was found to almost double the risk for AD, whereas the presence of anti-HSV IgG antibodies did not affect the risk.

Place, publisher, year, edition, pages
2015. Vol. 11, no 6, 593-599 p.
Keyword [en]
Alzheimer's disease, Cohort study, Dementia, HSV, Herpes, Herpes simplex
National Category
Microbiology in the medical area Neurosciences Neurology
Identifiers
URN: urn:nbn:se:umu:diva-100524DOI: 10.1016/j.jalz.2014.04.522ISI: 000357231900002PubMedID: 25043910OAI: oai:DiVA.org:umu-100524DiVA: diva2:792483
Available from: 2015-03-04 Created: 2015-03-04 Last updated: 2017-05-11Bibliographically approved

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Lövheim, HugoGilthorpe, JonathanAdolfsson, RolfNilsson, Lars-GöranElgh, Fredrik
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