Change search
ReferencesLink to record
Permanent link

Direct link
Targeting Epstein-Barr virus infection as an intervention against multiple sclerosis
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2015 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 131, no 2, 69-79 p.Article, review/survey (Refereed) Published
Abstract [en]

We here review contemporary data on genetic and environmental risk factors, particularly Epstein-Barr virus infection, for multiple sclerosis. There is an important immunogenetic etiological factor for multiple sclerosis. However, a general assumption is that immune defense genes are activated by the environment, basically by infections. We contend that the relationship between infectious mononucleosis and multiple sclerosis cannot be completely explained by genetics and inverse causality. Epstein-Barr infection as indicated by positive serology is an obligatory precondition for multiple sclerosis, which is a stronger attribute than a risk factor only. Data on events in the early pathogenesis of multiple sclerosis are cumulating from bio-banks with presymptomatic specimens, but there is only little information from the critical age when Epstein-Barr infection including infectious mononucleosis is acquired, nor on the detailed immunological consequences of this infection in individuals with and without multiple sclerosis. We discuss how focused bio-banking may elaborate a rationale for the development of treatment or vaccination against Epstein-Barr virus infection. A cohort in which intervention against Epstein-Barr infections was performed should be the object of neurological follow-up.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 131, no 2, 69-79 p.
Keyword [en]
Multiple sclerosis, Epstein-Barr virus, neuroepidemiology, bio-banks, vaccination, risk factors
National Category
Neurosciences Neurology
URN: urn:nbn:se:umu:diva-100280DOI: 10.1111/ane.12294ISI: 000348873400001PubMedID: 25208981OAI: diva2:793414
Available from: 2015-03-06 Created: 2015-02-27 Last updated: 2015-03-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Sundström, Peter
By organisation
Clinical Neuroscience
In the same journal
Acta Neurologica Scandinavica

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link