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Natural green coating inhibits adhesion of clinically important bacteria
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, 8287- p.Article in journal (Refereed) Published
Abstract [en]

Despite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015. Vol. 5, 8287- p.
National Category
Biomaterials Science Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-100278DOI: 10.1038/srep08287ISI: 000348903900002PubMedID: 25655943OAI: oai:DiVA.org:umu-100278DiVA: diva2:793435
Available from: 2015-03-06 Created: 2015-02-27 Last updated: 2017-12-04Bibliographically approved

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Rzhepishevska, OlenaRamstedt, Madeleine

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