Change search
ReferencesLink to record
Permanent link

Direct link
MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets
Show others and affiliations
2015 (English)In: Molecular Psychiatry, ISSN 1359-4184, E-ISSN 1476-5578, Vol. 20, no 4, 472-481 p.Article in journal (Refereed) Published
Abstract [en]

Sequence analysis of 13 microRNA (miRNA) genes expressed in the human brain and located in genomic regions associated with schizophrenia and/or bipolar disorder, in a northern Swedish patient/control population, resulted in the discovery of two functional variants in the MIR137 gene. On the basis of their location and the allele frequency differences between patients and controls, we explored the hypothesis that the discovered variants impact the expression of the mature miRNA and consequently influence global mRNA expression affecting normal brain functioning. Using neuronal-like SH-SY5Y cells, we demonstrated significantly reduced mature miR-137 levels in the cells expressing the variant miRNA gene. Subsequent transcriptome analysis showed that the reduction in miR-137 expression led to the deregulation of gene sets involved in synaptogenesis and neuronal transmission, all implicated in psychiatric disorders. Our functional findings add to the growing data, which implicate that miR-137 has an important role in the etiology of psychiatric disorders and emphasizes its involvement in nervous system development and proper synaptic function.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015. Vol. 20, no 4, 472-481 p.
Keyword [en]
genome scan metaanalysis, central nervous system, bipolar disorder, microRNA expression, association analysis, wide association, knockout mice, stem cells, schizophrenia, miR 137
National Category
Psychiatry Neurosciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
URN: urn:nbn:se:umu:diva-101495DOI: 10.1038/mp.2014.53ISI: 000351780800008PubMedID: 24888363OAI: diva2:799780
Available from: 2015-03-31 Created: 2015-03-31 Last updated: 2015-12-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nordin Adolfsson, AnnelieAdolfsson, Rolf
By organisation
In the same journal
Molecular Psychiatry
PsychiatryNeurosciencesMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 74 hits
ReferencesLink to record
Permanent link

Direct link