Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
2015 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 112, no 1, 162-166 p.Article in journal (Refereed) Published
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
Place, publisher, year, edition, pages
2015. Vol. 112, no 1, 162-166 p.
IGF-I, ovarian cancer, histological subtypes, carcinogenesis, type I/type II, dualistic pathway
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-100776DOI: 10.1038/bjc.2014.566ISI: 000348280900024PubMedID: 25349976OAI: oai:DiVA.org:umu-100776DiVA: diva2:800112