Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes
2014 (English)In: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 11, no 12, 1519-1528 p.Article in journal (Refereed) Published
Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the cellular processes that have been linked to the Elongator complex and discuss its role in tRNA modification and regulation of translation. We also describe additional gene products essential for formation of ncm(5) and mcm(5) side chains at U-34 and their influence on Elongator activity.
Place, publisher, year, edition, pages
Taylor & Francis, 2014. Vol. 11, no 12, 1519-1528 p.
elongator complex, KTI genes, SIT4, SAP genes, tRNA wobble uridine modifications, translation, uveromyces lactis gamma-toxin
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-101625DOI: 10.4161/15476286.2014.992276ISI: 000350568300005PubMedID: 25607684OAI: oai:DiVA.org:umu-101625DiVA: diva2:801497