umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Show others and affiliations
2014 (English)In: RNA Biology, ISSN 1547-6286, E-ISSN 1555-8584, Vol. 11, no 12, 1519-1528 p.Article in journal (Refereed) Published
Abstract [en]

Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the cellular processes that have been linked to the Elongator complex and discuss its role in tRNA modification and regulation of translation. We also describe additional gene products essential for formation of ncm(5) and mcm(5) side chains at U-34 and their influence on Elongator activity.

Place, publisher, year, edition, pages
Taylor & Francis, 2014. Vol. 11, no 12, 1519-1528 p.
Keyword [en]
elongator complex, KTI genes, SIT4, SAP genes, tRNA wobble uridine modifications, translation, uveromyces lactis gamma-toxin
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-101625DOI: 10.4161/15476286.2014.992276ISI: 000350568300005PubMedID: 25607684OAI: oai:DiVA.org:umu-101625DiVA: diva2:801497
Available from: 2015-04-09 Created: 2015-04-07 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Karlsborn, TonyTukenmez, HasanXu, FuXu, HaoByström, Anders S

Search in DiVA

By author/editor
Karlsborn, TonyTukenmez, HasanXu, FuXu, HaoByström, Anders S
By organisation
Department of Molecular Biology (Faculty of Science and Technology)
In the same journal
RNA Biology
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 299 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf