Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet
2015 (English)In: Physiology and Behavior, ISSN 0031-9384, E-ISSN 1873-507X, Vol. 140, 1-7 p.Article in journal (Refereed) Published
Ingestion of energy rich high fat diets is one of the determining factors associated with the obesity epidemic. Therefore, much can be learned from studies of obesity-related substances given to animals fed a high fat diet.The progesterone metabolite allopregnanolone is a potent positive modulator of the gamma-aminobutyric acid(GABA)A-receptor, and both allopregnanolone and GABA have been implicated in evoking hyperphagia. In this study, food intake and body weight gain were investigated during repeated allopregnanolone exposure. Male Wistar rats were studied when fed chow ad libitum, with chow access for 4h per day or with 45% high fat pellets for 4 h per day. Rats on the high fat diet were separated into obesity prone and obesity resistant individuals.Subcutaneous injections of allopregnanolone were given once daily overﬁve consecutive days. Repeated exposure to allopregnanolone lead to increased weight gain, signiﬁcantly so in schedule fed rats on a high fat diet. The increased weight gain was correlated to an increased energy intake. Both obesity resistant and obesityprone rats responded to allopregnanolone with increased weight gain. Obesity resistant rats treated with allopregnanolone increased their energy intake and ate as much as vehicle treated obesity prone rats. Their weight gain was also increased to the level of obesity prone rats injected with just the vehicle carrier oil. Thus, it appears that allopregnanolone may be one of the endogenous factors involved in weight gain, especiallywhen the diet is rich in fat.
Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 140, 1-7 p.
Allopregnanolone Neurosteroid Weight gain Food intake Scheduled feeding High fat diet
Neurosciences Physiology Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:umu:diva-101793DOI: 10.1016/j.physbeh.2014.12.012ISI: 000349588400001OAI: oai:DiVA.org:umu-101793DiVA: diva2:802662