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The function of glycine decarboxylase complex is optimized to maintain high photorespiratory flux via buffering of its reaction products
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.ORCID iD: 0000-0001-5900-7395
2014 (English)In: Mitochondrion (Amsterdam. Print), ISSN 1567-7249, E-ISSN 1872-8278, Vol. 19, 357-364 p.Article in journal (Refereed) Published
Abstract [en]

Oxidation of glycine in photorespiratory pathway is the major flux through mitochondria of C3 plants in the light. It sustains increased intramitochondrial concentrations of NADH and NADPH, which are required to engage the internal rotenone-insensitive NAD(P)H dehydrogenases and the alternative oxidase. We discuss here possible mechanisms of high photorespiratory flux maintenance in mitochondria and suggest that it is fulfilled under conditions where the concentrations of glycine decarboxylase reaction products NADH and CO2 achieve an equilibrium provided by malate dehydrogenase and carbonic anhydrase, respectively. This results in the removal of these products from the glycine decarboxylase multienzyme active sites and in the maintenance of their concentrations at levels sufficiently low to prevent substrate inhibition of the reaction. 

Place, publisher, year, edition, pages
2014. Vol. 19, 357-364 p.
Keyword [en]
Glycine decarboxylase, Non-coupled electron transport, Ma late dehydrogenase, Carbonic anhydrase, otorespiration
National Category
Cell Biology Genetics
URN: urn:nbn:se:umu:diva-99235DOI: 10.1016/j.mito.2014.01.001ISI: 000346624800030OAI: diva2:805932
Available from: 2015-04-17 Created: 2015-02-04 Last updated: 2015-04-29Bibliographically approved

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Gardeström, Per
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Umeå Plant Science Centre (UPSC)Department of Plant Physiology
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