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Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)
2015 (English)In: Virulence, ISSN 2150-5608, Vol. 6, no 3, 188-195 p.Article, review/survey (Refereed) Published
Abstract [en]

Periodontitis is an infection-induced inflammatory disease that causes loss of the tooth supporting tissues. Much focus has been put on comparison of the microbial biofilm in the healthy periodontium with the diseased one. The information arising from such studies is limited due to difficulties to compare the microbial composition in these two completely different ecological niches. A few longitudinal studies have contributed with information that makes it possible to predict which individuals who might have an increased risk of developing aggressive forms of periodontitis, and the predictors are either microbial or/and host-derived factors. The most conspicuous condition that is associated with disease risk is the presence of Aggregatibacter actinomycetemcomitans at the individual level. This Gram-negative bacterium has a great genetic variation with a number of virulence factors. In this review we focus in particular on the leukotoxin that, based on resent knowledge, might be one of the most important virulence factors of A. actinomycetemcomitans.

Place, publisher, year, edition, pages
Taylor & Francis , 2015. Vol. 6, no 3, 188-195 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Infectious Diseases
Identifiers
URN: urn:nbn:se:umu:diva-99665DOI: 10.4161/21505594.2014.982428ISI: 000353286300004PubMedID: 25494963OAI: oai:DiVA.org:umu-99665DiVA: diva2:806179
Available from: 2015-04-18 Created: 2015-02-10 Last updated: 2015-05-19Bibliographically approved

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Höglund Åberg, CarolaKelk, PeymanJohansson, Anders
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CiteExportLink to record
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