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Whole blood viscosity in plasma cell dyscrasias
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
2015 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 48, no 3, 122-124 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Plasmaor serum hyperviscosity in plasma cell dyscrasias (PCD) has been described as a risk factor for circulatory disturbances. Whole blood viscosity (WBV) would theoretically be a better biomarker but has not been studied in PCD. Design and methods: Plasma viscosity (PV) and WBV were measured in 89 subjects with PCD and in 60 healthy blood donors by free oscillation rheometry. A complete blood count was obtained using an automated hematology analyzer. Plasma proteins were quantitated by immunoturbidimetry. Results: The reference intervals for men & women were 1.16-1.36 & 1.16-1.38 mPa for PV, and 4.9-6.3 & 4.4-6.2 mPa for WBV, respectively. Of the PCD patients, 71% had PV above the reference limit and 40% were above the WBV limit. Multivariate analysis showed that WBV was independently related to hematocrit, PV, concentration of the monoclonal protein (M-protein), plasma fibrinogen concentration and albumin concentration. This model accounted for 76% of the variance in WBV. When the same model was applied to PV, only the concentration of the M-protein was significantly related and the model accounted only for 20% of the variance in PV. Conclusion: PV cannot be used as a surrogate marker for WBV in PCD patients. Whole blood viscosity should replace plasma viscosity in patients with PCD.

Place, publisher, year, edition, pages
2015. Vol. 48, no 3, 122-124 p.
Keyword [en]
Whole blood viscosity, Plasma viscosity, M-protein, Myeloma, MGUS
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:umu:diva-100768DOI: 10.1016/j.clinbiochem.2014.11.006ISI: 000348703300006PubMedID: 25526882OAI: oai:DiVA.org:umu-100768DiVA: diva2:807925
Available from: 2015-04-26 Created: 2015-03-09 Last updated: 2017-12-04Bibliographically approved

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