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Influences of a DRD2 polymorphism on updating of long-term memory representations and caudate BOLD activity: magnification in aging
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Karolinska Inst, ARC, S-11330 Stockholm, Sweden; Stockholm Univ, S-11330 Stockholm, Sweden; Stockholm Univ, Dept Psychol, S-11330 Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
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2015 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 36, no 4, 1325-1334 p.Article in journal (Refereed) Published
Abstract [en]

A number of genetic polymorphisms are related to individual differences in cognitive performance. Striatal dopamine (DA) functions, associated with cognitive performance, are linked to the TaqIA polymorphism of the DRD2/ANKK1 gene. In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIA polymorphism is related to reduced density of striatal DA D2 receptors. The resource-modulation hypothesis assumes that aging-related losses of neurochemical and structural brain resources modulate the extent to which genetic variations affect cognitive functioning. Here, we tested this hypothesis using functional MRI during long-term memory (LTM) updating in younger and older carriers and noncarriers of the A1-allele of the TaqIa polymorphism. We demonstrate that older A1-carriers have worse memory performance, specifically during LTM updating, compared to noncarriers. Moreover, A1-carriers exhibited less blood oxygen level-dependent (BOLD) activation in left caudate nucleus, a region critical to updating. This effect was only seen in older adults, suggesting magnification of genetic effects on functional brain activity in aging. Further, a positive relationship between caudate BOLD activation and updating performance among non-A1 carriers indicated that caudate activation was behaviorally relevant. These results demonstrate a link between the DRD2/ANKK1-TaqIA polymorphism and neurocognitive deficits related to LTM updating, and provide novel evidence that this effect is magnified in aging. Hum Brain Mapp 36:1325-1334, 2015.

Place, publisher, year, edition, pages
2015. Vol. 36, no 4, 1325-1334 p.
Keyword [en]
functional magnetic resonance imaging (fMRI),  memory,  aging,  dopamine,  DRD2,  updating,  striatum
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Neurosciences
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URN: urn:nbn:se:umu:diva-102513DOI: 10.1002/hbm.22704ISI: 000351737800007PubMedID: 25486867OAI: oai:DiVA.org:umu-102513DiVA: diva2:808293
Available from: 2015-04-28 Created: 2015-04-28 Last updated: 2017-12-04Bibliographically approved

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