Change search
ReferencesLink to record
Permanent link

Direct link
Increased bilateral frontal connectivity during working memory in young adults under the influence of a dopamine D1 receptor antagonist.
2012 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 32, no 48, 17067-72 p.Article in journal (Refereed) Published
Abstract [en]

Increased frontal bilaterality in old compared with young adults during cognitive performance is a common finding in human functional neuroimaging studies. Age-related reductions in laterality are a widely debated topic and their origins and consequences may be manifold. The current study demonstrates that a dopamine (DA) D1 antagonist induces increased frontal bilateral connectivity in healthy young adults revealed by functional magnetic resonance imaging during a spatial working memory task. Moreover, increases in functional connectivity between right and left prefrontal cortex during the pharmacological challenge were associated with maintaining performance on drug. To our knowledge, this is the first study to pharmacologically induce increased frontal bilateral functional connectivity during a cognitive task in young adults and to show that increased bilaterality is associated with less severe cognitive impairment under the influence of a DA receptor antagonist.

Place, publisher, year, edition, pages
2012. Vol. 32, no 48, 17067-72 p.
National Category
URN: urn:nbn:se:umu:diva-102518DOI: 10.1523/JNEUROSCI.1431-12.2012PubMedID: 23197700OAI: diva2:808299
Available from: 2015-04-28 Created: 2015-04-28 Last updated: 2015-04-28

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Rieckmann, Anna
In the same journal
Journal of Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link