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Reoperation after oesophageal cancer surgery in relation to long-term survival: a population-based cohort study
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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2014 (Engelska)Ingår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 4, nr 3, artikel-id e004648Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: The influence of reoperation on long-term prognosis is unknown. In this large population-based cohort study, it was aimed to investigate the influence of a reoperation within 30 days of oesophageal cancer resection on survival even after excluding the initial postoperative period.

DESIGN: This was a nationwide population-based retrospective cohort study.

SETTING: All hospitals performing oesophageal cancer resections during the study period (1987-2010) in Sweden.

PARTICIPANTS: Patients operated for oesophageal cancer with curative intent in 1987-2010.

PRIMARY AND SECONDARY OUTCOMES: Adjusted HRs of all cause, early and late mortality up to 5 years after reoperation following oesophageal cancer resection.

RESULTS: Among 1822 included patients, the 200 (11%) who were reoperated had a 27% increased HR of all-cause mortality (adjusted HR 1.27, 95% CI 1.05 to 1.53) and 28% increased HR of disease-specific mortality (adjusted HR 1.28, 95% CI 1.04 to 1.59), compared to those not reoperated. Reoperation for anastomotic insufficiency in particular was followed by an increased mortality (adjusted HR 1.82, 95% CI 1.19 to 2.76).

CONCLUSIONS: This large and population-based nationwide cohort study shows that reoperation within 30 days after primary oesophageal resection was associated with increased mortality, even after excluding the initial 3 months after surgery. This finding stresses the need to consider any actions that might prevent complications and reoperation after oesophageal cancer resection.

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2014. Vol. 4, nr 3, artikel-id e004648
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URN: urn:nbn:se:umu:diva-102760DOI: 10.1136/bmjopen-2013-004648ISI: 000333921300058PubMedID: 24650808OAI: oai:DiVA.org:umu-102760DiVA, id: diva2:809567
Tillgänglig från: 2015-05-04 Skapad: 2015-05-04 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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