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Microcirculation changes during liver resection: a clinical study
Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
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2014 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 94, 47-51 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively.

PATIENTS AND METHODS: 40 patients undergoing hepatic resection were included and grouped according to if they were operated with a major or minor resection. Hepatic microcirculation measurements were made intra-operatively before and after liver resection with sidestream dark-field (SDF) imaging. Red blood cell velocity (RBCV), sinusoidal diameter and functional sinusoidal density were determined.

RESULTS: After hepatic resection RBCV increased in both the minor and major groups (44 μm/s, P=0.016 and 121 μm/s, P=0.002). RBCV in patients with histological damages was 225 (148-464) μm/s vs. 161 (118-329) μm/s in patients with no damage (P=0.016).

CONCLUSION: A hepatic resection leads to an increase of sinusoidal RBCV. SDF imaging could potentially be used to intraoperatively identify histological damages.

Place, publisher, year, edition, pages
2014. Vol. 94, 47-51 p.
National Category
URN: urn:nbn:se:umu:diva-102773DOI: 10.1016/j.mvr.2014.05.002ISI: 000339858000007PubMedID: 24840670OAI: diva2:809574
Available from: 2015-05-04 Created: 2015-05-04 Last updated: 2015-07-30Bibliographically approved

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Blind, Per-Jonas
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