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Calcium affinity of human α-actinin1
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0003-3044-1256
2015 (English)In: PeerJ, Vol. 3, e944Article in journal (Refereed) Published
Abstract [en]

Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and the EF-hand motifs. Therefore, any functional or structural distinction should involve this part of the protein. To investigate this further, the calcium affinities of these three isoforms of α-actinin 1 have been determined by isothermal calorimetry.

Place, publisher, year, edition, pages
2015. Vol. 3, e944
Keyword [en]
EF-hand, α-actinin, calcium binding
National Category
Biochemistry and Molecular Biology
Research subject
URN: urn:nbn:se:umu:diva-102996DOI: 10.7717/peerj.944ISI: 000354391100004OAI: diva2:811947
Carl Tryggers foundation
Available from: 2015-05-13 Created: 2015-05-13 Last updated: 2015-07-10Bibliographically approved

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Backman, Lars
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