umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissues ex vivo
Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF). Dept. of Engineering Sciences and Mathematics, Luleå University of Technology, Luleå, Sweden.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF). Dept. of Engineering Sciences and Mathematics, Luleå University of Technology, Luleå, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. (Njurcancer)ORCID iD: 0000-0002-4121-3753
Show others and affiliations
2015 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 39, no 3, 198-207 p.Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p<0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer.

Place, publisher, year, edition, pages
Taylor & Francis, 2015. Vol. 39, no 3, 198-207 p.
Keyword [en]
Prostate cancer, radical prostatectomy, raman spectroscopy, tactile resonance technology, tissue autofluorescence
National Category
Medical Engineering Medical Laboratory and Measurements Technologies Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-103285DOI: 10.3109/03091902.2015.1021430OAI: oai:DiVA.org:umu-103285DiVA: diva2:812645
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nyberg, MorganJalkanen, VilleLjungberg, BörjeBergh, AndersLindahl, Olof A.
By organisation
Centre for Biomedical Engineering and Physics (CMTF)Department of Applied Physics and ElectronicsUrology and AndrologyPathologyRadiation Physics
In the same journal
Journal of Medical Engineering & Technology
Medical EngineeringMedical Laboratory and Measurements TechnologiesCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 143 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf