Recent functional insights into the role of (p)ppGpp in bacterial physiology
2015 (English)In: Nature Reviews Microbiology, ISSN 1740-1526, E-ISSN 1740-1534, Vol. 13, no 5, 298-309 p.Article, review/survey (Refereed) Published
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p) ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p) ppGpp metabolism and (p) ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p) ppGpp. We also discuss the structural basis of transcriptional regulation by (p) ppGpp and the role of (p) ppGpp in GTP metabolism and in the emergence of bacterial persisters.
Place, publisher, year, edition, pages
Macmillan Publishers Ltd., 2015. Vol. 13, no 5, 298-309 p.
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:umu:diva-103139DOI: 10.1038/nrmicro3448ISI: 000353062500010PubMedID: 25853779OAI: oai:DiVA.org:umu-103139DiVA: diva2:813409
This work was supported by the European Regional Development Fund through the Centre of Excellence in Chemical Biology (V.H. and T.T.); by the Estonian Science Foundation (grants ETF9012 and PUT37 (V.H.), and grant ETF9020 (G.C.A.)); by Umeå University, the Swedish Research Council, the Ragnar Söderberg Foundation and the Kempe Foundation (V.H.); by the US National Institutes of Health (grant GM087350 (K.S.M.)); and by a European Research Council Advanced Investigator Grant (294517; PERSIST) and a Novo Nordisk Foundation Laureate Research Grant (K.G.).2015-05-222015-05-182015-11-11Bibliographically approved