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Recent functional insights into the role of (p)ppGpp in bacterial physiology
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia. (Grupp Vasili Hauryliuk)
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia. (Grupp Vasili Hauryliuk)
Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia.
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2015 (English)In: Nature Reviews Microbiology, ISSN 1740-1526, E-ISSN 1740-1534, Vol. 13, no 5, 298-309 p.Article, review/survey (Refereed) Published
Abstract [en]

The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p) ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p) ppGpp metabolism and (p) ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p) ppGpp. We also discuss the structural basis of transcriptional regulation by (p) ppGpp and the role of (p) ppGpp in GTP metabolism and in the emergence of bacterial persisters.

Place, publisher, year, edition, pages
Macmillan Publishers Ltd., 2015. Vol. 13, no 5, 298-309 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-103139DOI: 10.1038/nrmicro3448ISI: 000353062500010PubMedID: 25853779OAI: oai:DiVA.org:umu-103139DiVA: diva2:813409
Funder
Novo Nordisk
Note

This work was supported by the European Regional Development Fund through the Centre of Excellence in Chemical Biology (V.H. and T.T.); by the Estonian Science Foundation (grants ETF9012 and PUT37 (V.H.), and grant ETF9020 (G.C.A.)); by Umeå University, the Swedish Research Council, the Ragnar Söderberg Foundation and the Kempe Foundation (V.H.); by the US National Institutes of Health (grant GM087350 (K.S.M.)); and by a European Research Council Advanced Investigator Grant (294517; PERSIST) and a Novo Nordisk Foundation Laureate Research Grant (K.G.).

Available from: 2015-05-22 Created: 2015-05-18 Last updated: 2017-12-04Bibliographically approved

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Hauryliuk, VasiliAtkinson, Gemma C.

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