Change search
ReferencesLink to record
Permanent link

Direct link
An epidemiologic risk prediction model for ovarian cancer in Europe: the EPIC study
Show others and affiliations
2015 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 112, no 7, 1257-1265 p.Article in journal (Refereed) Published
Abstract [en]

Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents. Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European Prospective Investigation into Cancer and Nutrition study. Results: Older age at menopause, longer duration of hormone replacement therapy, and higher body mass index were included as increasing ovarian cancer risk, whereas unilateral ovariectomy, longer duration of oral contraceptive use, and higher number of full-term pregnancies were decreasing risk. The discriminatory power (overall concordance index) of this model, as examined with five-fold cross-validation, was 0.64 (95% confidence interval (CI): 0.57, 0.70). The ratio of the expected to observed number of ovarian cancer cases occurring in the first 5 years of follow-up was 0.90 (293 out of 324, 95% CI: 0.81-1.01), in general there was no evidence for miscalibration. Conclusion: Our ovarian cancer risk model containing only epidemiological data showed modest discriminatory power for a Western European population. Future studies should consider adding informative biomarkers to possibly improve the predictive ability of the model.

Place, publisher, year, edition, pages
2015. Vol. 112, no 7, 1257-1265 p.
Keyword [en]
ovarian cancer, risk model, reproductive risk factors
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-103554DOI: 10.1038/bjc.2015.22ISI: 000352145300015PubMedID: 25742479OAI: diva2:813827
Available from: 2015-05-25 Created: 2015-05-21 Last updated: 2016-02-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Idahl, Annika
By organisation
Obstetrics and Gynaecology
In the same journal
British Journal of Cancer
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 48 hits
ReferencesLink to record
Permanent link

Direct link